Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong female predilection. Both maternal and fetal mortality and morbidity are still significantly increased despite improvements in outcomes. Petri M. Systemic lupus erythematosus and pregnancy. Systemic lupus erythematosus in pregnancy. Materna … Rheum Dis Clin North America 20:87117, 1994. This monograph provides an overview of the role of an obstetrician–gynecologist (ob-gyn) in the treatment of SLE … Pregnancy remains a commonly encountered but high-risk situation in this setting. Ann Intern Med 94:667-677, 1981. SLE occurs frequently in women at reproductive age, and is associated with pregnancy complications. Pregnancy, though, is considered high-risk due to a combination of maternal (lupus flare, diabetes, pre-eclampsia) and fetal (miscarriage, intrauterine fetal demise, preterm birth, intrauterine growth restriction, congenital heart block) risks. However, pregnancy with the most common – and serious – type of the disease of lupus called systemic lupus erythematosus involves special implications for prenatal care. Attribution of early losses to SLE is often not possible, as early pregnancy losses are also common in the general population. Active SLE at the time of conception is a strong predictor of adverse maternal and obstetrical outcomes [ 1-3 ]. Flares typically occur during the first or second trimester and are often mild. In fact, many women with this disease give birth to healthy children. Systemic Lupus Erythematosus (SLE) is an autoimmune disease that occurs when the immune system begins to attack the body’s own tissues. 6 In patients with SLE, pregnancy loss occurs mostly during the first trimester. The key to a successful pregnancy is knowing how lupus affects the body and keeping the disease under control. Posted On: February 16, 2017 By Nathan D. Fox, MD. As SLE onset is often in young adulthood, pregnancy is common and is usually successful. Having lupus doesn’t mean you can’t have a baby. Usually, it presents in women in puberty or early adulthood. Systemic Lupus Erythematosus (SLE) and Pregnancy. PREGNANCY PLANNING — Ideally, disease should be quiescent for six months prior to systemic lupus erythematosus (SLE) patients attempting conception. Pregnancy loss Fetal loss rates for pregnancy complicated by lupus have decreased over the past 40 years, from a mean of 40% to 17%. And while pregnant women with active lupus may have symptoms, only 10 percent of those with SLE experience severe episodes during pregnancy. Advancing technology and better understanding of the disease and its effects on the body have improved pregnancy outcomes over … Systemic lupus erythematosus in pregnancy Patrick Gordon, Trevor Beedham, Munther Khamashta, David D’Cruz When a woman is known to have systemic lupus erythematosis, planning and preparation can improve the outcome of pregnancy and reduce the severity of … Pregnancy is no longer considered an impossibility if you have lupus. As SLE is associated with higher risk of adverse pregnancy outcomes, such as preeclampsia and intrauterine growth restriction, compared with the general population, the patient underwent supplementary fetal surveillance with Doppler sonography in the third trimester at monthly intervals. ABSTRACT: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease most commonly involving skin, joints, and kidneys. 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